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Cardiovascular Detective

Cardiovascular Detective, Inc. was formed to meet the increasing need for outsourcing pre-clinical contract research in the field of cardiovascular research. There are many CRO's that offer similar services, however, Cardiovascular Detective is the only organization that is a network of highly trained university scientists in the field of cardiovascular research.

General Capabilities

  • Hemodynamics Screening
  • Conscious Rodent Telemetry (BP, HR, RF)
  • Conscious Rodent Tethering (BP, HR, RF)
  • Aortic & mesenteric reactivity & vascular stiffening
  • Renal Function Screening
  • Cardiac hemodynamics (dp/dt, LVSP, LVEDP)
  • Isolated aortic rings
  • Isolated heart
  • Echocardiography (EF, CO, LVDD, LVSD)
  • Doppler echocardiography measurement of PA flow velocity
  • Catheter-based measurements of LV, RV, and PVR 

Heart Failure

  • Isoproterenol and Angiotensin-induced models of cardiac hypertrophy and fibrosis
  • LAD coronary artery ligation in mice and rats
  • Transverse aortic constriction in mice and rats
  • Dahl SS model of diastolic heart failure
  • DOCA-Salt + Unilateral Nephrectomy Rats
  • Tachypacing induced model in rabbits and dogs
  • Myocardial Ischemia/Reperfusion

Pulmonary Hypertension

  • Hypoxia-induced pulmonary hypertension in mice and rat
  • Hypoxia induced plus SU5416 (VEGF-R inhibitor) pulmonary hypertension in mice and rats
  • Neonatal calf hypoxia
  • Monocrotaline-induced pulmonary fibrosis (arterial fibrosis leading to hypertension)

Clinical R&D, Regulartory and Ethics Submission

  • Focusing on unique clinical trials that need sensitive patient population and strong regularoty & scientific support
  • Qualified and expereienced investigators and cetners (e.g. phase 1 centers)
  • Our clinical pharmacology specialists are ready to assist your project



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