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Panthera Solutions Ltd provides preclinical disease models for evaluation of efficacy in vivo and in vitro over a broad spectrum of diseases. Studies are performed by experienced scientists with expertise in their own specialist research areas using facilities world wide. Below is a list of the specific services that Panthera Solutions Ltd provides:
Inflammation
Acute / Non-immune
- Paw oedema
- Ear oedema
- Pleurisy
- Lung inflammation
- Air pouch - neutrophil chemotaxis
- Air pouch - monocyte chemotaxis
- Peritonitis
- Periodontitis
- Pancreatitis
- Dermatitis
Arthritis / Fibrosis
Arthritis
- Kaolin-induced arthritis
- Antigen-induced arthritis
- Monoarticular arthritis - Temporomandibular joint
- Adjuvant-induced arthritis
- Collagen-induced arthritis
GI Disease
- Colitis / IBD - TNBS-induced (Th1 dominant)
- Colitis / IBD - DSS-induced (Th2 dominant)
- Irritable bowel syndrome
- NSAID gastropathy
- Anti-secretory action (gastric pH)
- Ulcerogenicity
- Gastric ulcer healing
- Intestinal motility in vitro
- Cyclooxygenase selectivity
Pain
(using paw licking, Randall & Selitto, Hargreaves & Von Frey tests)
- Acute inflammatory pain
- Chronic inflammatory pain
- Hyperalgesia
- Writhing test
- Formalin test
- Hot plate test
- Tail flick test
- Tail immersion test
- Neuropathic pain
CNS
- Acute EAE (MBP-induced)
- Spinal cord injury
- Rotarod test - motor coordination
- Elevated plus-maze - anxiety
- Forced swimming - depression
- Induced sleep - hypnotic detection
Cardiovascular - shock / sepsis
- Endotoxaemia / sepsis
- Cecal ligation and puncture-induced sepsis
- Splanchnic Artery Occlusion (SAO)
- Multiple Organ Dysfunction Syndrome (MODS)
- Ischaemia
Vascular Disorders
- Atherosclerosis - cholesterol-fed
- Atherosclerosis - Apo E KO
- Peripheral Artery Disease (PAD)
- Gangrene
- Erectile dysfunction
- Glaucoma
- Microvascular plasma leakage
- Vascular reactivity
Respiratory
- Pulmonary function - Pehn apparatus
- Airway hyperreactivity in vivo
- Airway reactivity in vitro
Cancer
- Melanoma
- Breast cancer
- Prostate cancer
- Angiogenesis
- Tumour growth and vascularity
Cell function tests
- Cell proliferation
- Cell adhesion
- Cell apoptosis
Platelets
- Platelet adhesion in vitro
- Platelet aggregation in vitro
Assays
- COX
- Leukotriene release
- Nitric oxide synthase
- NF-kB activation
- ECE
- ACE
- SOD
If a specific model is not listed on the website, please contact UpReach.
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